Lineage 1

## 62.2% of the genes are called significant when we require the adjusted p-value to be smaller than 0.01

Scaled log expression of lineage 1. Heatmap of top 500 significant genes detected by three methods.

Log expression of lineage 1. Heatmap of top 500 significant genes detected by three methods.

## [1] 1

Lineage 2

## 76.16% of the genes are called significant when we require the adjusted p-value to be smaller than 0.01

Scaled log expression of lineage 2. Heatmap of top 500 significant genes detected by three methods.

Log expression of lineage 2. Heatmap of top 500 significant genes detected by three methods.

## [1] 1

Most of the genes (~70%) are called significant under a commonly used significant level 0.01.
LineagePulse works well in detecting time-varying genes. However, it is very sensitive to outliers: several of the most significant genes are detected simply due to outliers (?) as shown in the heatmap.