Lineage 1

Percentage of genes called significant as we change q-value threshold

## 62.2% of the genes are called significant when we require the adjusted p-value to be smaller than 0.01

Heatmap of significant genes

Scaled log expression of lineage 1. Heatmap of top 500 significant genes detected by three methods.

Log expression of lineage 1. Heatmap of top 500 significant genes detected by three methods.

Visualization of 9 most significant genes

Visualization of 9 least significant genes

Venn Diagram

## [1] 1

Lineage 2

Percentage of genes called significant as we change q-value threshold

## 76.16% of the genes are called significant when we require the adjusted p-value to be smaller than 0.01

Heatmap of significant genes

Scaled log expression of lineage 2. Heatmap of top 500 significant genes detected by three methods.

Log expression of lineage 2. Heatmap of top 500 significant genes detected by three methods.

Visualization of 9 most significant genes

Visualization of 9 least significant genes

Venn Diagram

## [1] 1

Observation